Laboratory work for a patient with a suspected autoimmune disorder typically begins with an ANA screen. A properly structured cascade of screen and confirmatory serology tests can greatly assist physicians with the proper diagnosis of most autoimmune diseases.
GSD offers a variety of ANA EIA kits to fit sensitivity/specificity needs of virtually any diagnostic algorithm.
Please contact us for ordering information.
Connective tissue disorders (CTD’s), also called systemic autoimmune diseases, represent a subclass of the broad category of autoimmune disease. As with all autoimmune disorders, CTD’s are caused by an inappropriate immune response in which the body produces antibodies to itself. Connective tissue disease often
affects two major structural molecules: collagen and elastin. Patients with a CTD typically experience inflammation of and damage to collagen and elastin. Disorders include polymyositis, Sjögren syndrome, systemic lupus erythematosus (SLE), systemic sclerosis, and others.
When left undiagnosed and untreated, autoimmune conditions can lead to long-term consequences and a diminished quality of life. Negative outcomes for untreated autoimmune disorders include: other autoimmune disease, general failure to thrive, osteoporosis, joint destruction, nephritis and cancer1,2,3,4.
A properly structured cascade of screen and confirmatory serology tests can greatly assist physicians with the proper diagnosis of a connective tissue disorder. Laboratory work for a patient with suspected connective tissue disorders typically begins with an ANA screen and a CCP screen. The ANA screen is very sensitive, but not very specific. The CCP screen is both sensitive and specific for the diagnosis of Rheumatoid Arthritis.
Depending on the outcomes of the ANA and CCP screens, additional testing may be required to determine the specific diagnosis. In the case of a positive ANA screen, a variety of automatic reflex tests can be performed. These automated cascades have been optimized to enable physicians to thoroughly test for a wide variety of possible conditions in a financially responsible way.
Benefits of proper diagnosis of autoimmune connective tissue disorders are numerous. For patients who are positively diagnosed, effective treatment options can be exercised to help slow disease progression4. Such treatments can improve quality of life for patients with autoimmune disorders5. A negative diagnostic
outcome can be equally as important to rule out suspected conditions, and help avoid expensive and unnecessary treatments6.